ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

American Society for Reproductive Medicine Annual Meeting 2020


Transfer of Diploid Somatic Cells Into Enucleated Oocytes to Induce Meiosis-Like Haploidization

Aysha Trout, Philip Xie, Robert Setton, Zev Rosenwaks, Gianpiero D. Palermo

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The Impact of Double-Stranded Sperm DNA Breaks on ICSI Outcome

Derek Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

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Evaluating the Ability of an Oocyte to Repair Fragmented Sperm Chromatin

Derek, Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

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Identifying the Best Method of Retrieving Spermatozoa with the Highest Genomic Integrity

Danielle Tavares, Alessandra Parrella, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

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The Use of Semipermeable Spheres Engulfed with Mouse Embryonic Stem Cells to Generate Male Germ Cells

Sherina Lawrence, Mounia Haddad, Philip Xie, , Zev Rosenwaks, Gianpiero D. Palermo

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Identifying the Gamete Responsible for ICSI Fertilization Failure

Stephanie Cheung, Philip Xie, Alessandra Parrella, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

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The Effects of Germline Mutations on the Ability of Surgically Retrieved Spermatozoa from Azoospermic Men to Support Embryonic Development

Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

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A Promising Ligand and Microfluidics Sperm Sex Selection Method

Stephanie Cheung, Philip Xie, Alessandra Parrella, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

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Epigenetic Effect of Abstinence time on the Reproductive Potential of Infertile Men

Brianne Barker, Alessandra Parrella, Sherina Lawrence, Zev Rosenwaks, Gianpiero D. Palermo

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Targeted ICSI Treatment in Globozoospermic Men According to Sperm PLCZ Content

Alessandra Parrella, Danielle Tavares, Philip Xie, Stephanie Cheung, Brianne Barker, Zev Rosenwaks, Gianpiero D. Palermo

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Manufacturing Oocytes Through Somatic Cell Nuclear Transfer

Aysha Trout, Philip Xie, Robert Setton, Zev Rosenwaks, Gianpiero D. Palermo

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Male Neogametogenesis to Generate Fully Developed Preimplantation Embryos

Sherina Lawrence, Philip Xie, Mounia Haddad, Allison Petrini, Zev Rosenwaks, Gianpiero D. Palermo

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Structural and Genomic Characterization of Globozoospermic Men

Alessandra Parrella, Philip Xie, Stephanie Cheung, Danielle Tavares, Zev Rosenwaks, Gianpiero D. Palermo

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The Impact of Spermatozoa Retrieved from Different Regions of the Epididymis on Reproductive Outcomes

Alessandra Parrella, June Wang, Danielle Tavares, Mounia Haddad, Zev Rosenwaks, Gianpiero D. Palermo

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A Novel Method to Attenuate Embryo Aneuploidy Due to Paternal Inheritance

Alessandra Parrella, Danielle Tavares, June Wang, Mounia Haddad, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

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Using Gene Expression Profiles of Ejaculates of NOA Men to Help Predict Successful Testicular Sperm Retrieval

Brianne Barker, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

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Development of a Novel Technique to Edit the Genome of the Male Gamete

June Wang, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

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The Impact of High Sperm Chromatin Fragmentation on Intrauterine Insemination Outcome

Mounia Haddad, Derek Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

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Using Mirror Copies of Parental Genomes to Generate Developmentally Competent Embryos

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

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The Embryonic Developmental Competence of Reconstructed Zygotes Using a Cloned Male Gamete

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

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Embryology Lab-on-a-Chip: Automated Oocyte Denudation Microfluidic Device

Amir Mokhtare, Philip Xie, Alireza Abbaspourrad, Zev Rosenwaks, Gianpiero D. Palermo

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