ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

American Society for Reproductive Medicine Annual Meeting 2019

Utilization of Ejaculated Specimen After ICSI Failure with Testicular Spermatozoa from Men with High DNA Fragmentation

Alessandra Parrella, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

A Step Toward Gene Remodeling of Mammalian Spermatozoa by CRISPR-Cas9

June Wang, Alessandra Parrella, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

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Evaluating the Ability of an Oocyte to Repair Fragmented Sperm Chromatin

Derek, Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

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The Nuclear and Cytoplasmic Maturity of Retrieved Oocytes Contribute to ICSI Outcome

Derek, Keating, Alessandra Parrella, Mohamad Irani, Zev Rosenwaks, Gianpiero D. Palermo

Characterization of Globozoospermia and the Efficacy of Assisted Oocyte Activation (AOA) in Afflicted Patients

Matthew Goldman, Philip Xie, Alessandra Parrella, Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

Assessing and Restoring Gamete Fertilizing Ability

Stephanie Cheung, Alessandra Parrella, Derek Keating, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

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Varicocele Diminishes Sperm Capacitation Function and the Chances of Generating a Pregnancy

Philip Xie, Alessandra Parrella, Alexander Travis, Zev Rosenwaks, James Kashanian, Gianpiero D. Palermo

ICSI Outcome Using Spermatozoa with Optimal Genome Characteristics

Alessandra Parrella, Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

Determining the Impact of Surgically Retrieved Spermatozoa from Azoospermic Men on Embryonic Development by Genomic Profiling

Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

Selecting Spermatozoa with Intact Chromatin May Reduce Embryo Aneuploidy

Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

Transit through the Male Genital Tract Increases Sperm Chromatin Fragmentation

Derek Keating, Philip Xie, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

Novel Ex Vivo Culture of Neonatal Mouse Testicular Organoid Maintained in a Hanging Droplet with Retinoic Acid

Philip Xie, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

Differentiation of Embryonic Stem Cells into Male Germ Line Cells in a Bioreactor Using Decellularized Seminiferous Tubule Matrix Immersed in a Conditioned Medium

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

Post-Meiotic Male Germ Cell Differentiation of Mouse Embryonic Stem Cells by Exposure to Conditioned Medium

Aysha Trout, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

Comprehensive Gene Expression Analysis by RNA Sequencing of Human Testicular Tissue Exosomes: Can We Predict The Presence of Sperm?

Joshua Stewart, Ayuko Hoshino, Philip Xie, Alessandra Parrella. David Lyden, Zev Rosenwaks, Gianpiero D. Palermo

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