ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

European Society of Human Reproduction and Embryology Annual Meeting 2017

Choosing the appropriate insemination method in assisted reproductive treatments based on sperm chromatin fragmentation

Derek Keating, Nigel Pereira, Stephen Chow, Alessandra Parrella, Marc Goldstein, Zev Rosenwaks, and Gianpiero D. Palermo

Topographic mapping of sperm chromatin fragmentation within the male reproductive tract and associated reproductive outcomes

Alexis Melnick, Nigel Pereira, Stephen Chow, Alessandra Parrella, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

A Simple Method to Differentiate Mouse Embryonic Stem Cells into Male Germ Cells

Vivian Lu, Alessandra Parrella, Stephen Chow, Claire O'Neill, Mohamad Irani, Zev Rosenwaks, and Gianpiero D. Palermo

Reevaluation of the Frequency and Characteristics of Aneuploidy of Surgically Retrieved Spermatozoa in Light of Enhanced Molecular Genetic Techniques

Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

The impact of semen parameters and number of dominant follicles on the outcome of intrauterine insemination

Stephen Chow, Mohamad Irani, Claire O'Neill, Zev Rosenwaks, and Gianpiero D. Palermo

Selection of spermatozoa with higher chromatin integrity through a microfluidics device

Alessandra Parrella, Nigel Pereira, Stephen Chow, Zev Rosenwaks, and Gianpiero D. Palermo

Importance of the Aging Male Gamete on ART Outcome

Philip Xie, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

Investigating the role of sperm-specific RNA to screen men with unexplained infertility

Vinay Gunnala, MD, Nigel Pereira, MD, Alessandra Parrella, BS, Stephanie Cheung, BS, Claire O'Neill, BS, Zev Rosenwaks, MD, and Gianpiero D. Palermo, MD, PhD

Determining embryo developmental competence by measuring expressivity of the paternal epigenome

Nigel Pereira, Alessandra Parrella, Stephanie Cheung, Claire O'Neill, Zev Rosenwaks, and Gianpiero D. Palermo

Profiling of human spermatozoal non-coding RNA to determine the male contribution to embryonic implantation potential

Pak Chung, Nigel Pereira, Alessandra Parrella, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

Role of Gender Selection in ART

Nora Nikprelevic, Stephanie Cheung, Claire O'Neill, Stephen Chow, Zev Rosenwaks, and Gianpiero D. Palermo

Unraveling the role of seminal fluid exosomes within the male reproductive tract

Arthur Clement, Nigel Pereira, Zev Rosenwaks, David Lyden, Ayuko Hoshino, Gianpiero D. Palermo