ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

European Society of Human Reproduction and Embryology Annual Meeting 2018

In Vitro Generation of Germ Cells from Human Induced Pluripotent Stem Cells

Mohamed Irani, Stephen Chow, Vivian Lu, Claire O’Neill, Alessandra Parrella, Diane Choi, Zev Rosenwaks, Gianpiero D. Palermo

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Differentiating Mouse Induced
Pluripotent Stem Cells into Male Germ Cells Through Embryoid Bodies

Vivian Lu, Alessandra Parrella, Stephen Chow, Claire O’Neill, Mohamad Irani, Spencer Connaughty, Aysha Trout, Zev Rosenwaks, and Gianpiero D. Palermo

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Feasibility of CRISPR-Cas9 on the Human Sperm Cell

Diane Choi, Alessandra Parrella, Brandon Chin, Claire O’Neill, Stephanie Cheung, Zev Rosenwaks, and  Gianpiero D. Palermo

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Reassessing the Prevalence of Aneuploidy in Sperm Retrieved from Different Levels of the Male Genital Tract

Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

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Comparison of Cap-Score™, TUNEL, and Semen Analysis in Couples Undergoing Timed Intercourse and IUI

Philip Xie, Alessandra Parrella, Alex Travis, Derek Keating, Zev Rosenwaks, and Gianpiero D. Palermo

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Genomic Profiling of Spermatogenetic Function in Azoospermic Men

Brandon Chin, Stephanie Cheung, Claire O’Neill, Zev Rosenwaks, and Gianpiero D. Palermo

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Differential Expression of Testicular Function Can Shed Light on Why Some NOA Men Successfully Yield Spermatozoa

Lilli Zimmerman, Claire O’Neill, Alessandra Parrella, Mohamad Irani, Zev Rosenwaks, and Gianpiero D. Palermo

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Characterization of Spermatogenic Function in NOA Men Aiming at Predicting Success of Testicular Sperm Retrieval

Claire O’Neill, Alessandra Parrella, Mohamad Irani, Zev Rosenwaks, and Gianpiero D. Palermo

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The Proportion of Immature/Compromised Oocytes Impairs Ooplasmic Maturity if the Mature Cohort Retrieved

Stephen Chow, Alessandra Parrella, Mohamad Irani, Zev Rosenwaks, and Gianpiero D. Palermo

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A Proposed Method to Minimize Male Gamete Contribution to Aneuploidy in the Embryo Cohort

Alexis Melnick, Alessandra Parrella, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

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Querying Gene Expression to Profile Human Spermatogenesis in Infertile Men

Nigel Pereira, Alessandra Parrella, Claire O’Neill, Zev Rosenwaks, and Gianpiero D. Palermo

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