ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

European Society of Human Reproduction and Embryology Annual Meeting 2021

Morphokinetic Development By Time-Lapse Imaging of Conceptuses Generated from Artificial Oocytes

Aysha Trout, Philip Xie, Allison Petrini, Zev Rosenwaks, Gianpiero D. Palermo

ASRM 2020 donor cell poster FINAL AT.jpg

Artificial Oocytes: From Somatic Cells to Fertile Pups

Olena Kocur, Aysha Trout, Philip Xie, Allison Petrini, Zev Rosenwaks, Gianpiero D. Palermo

ESHRE FVB v BDF poster VF.jpg

The Correlation Between Sperm Chromatic Fragmentation and Intrauterine Insemination Outcome

Mounia Haddad, Danielle Tavares, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

The correlation between sperm chromatin fragmentation and intrauterine insemination outcome.jpg

Selecting Spermatozoa With the Highest Genomic Integrity in Order to Enhance Clinical Outcomes in Men With High DNA Fragmentation Levels

Danielle Tavares, Philip Xie, Mounia Haddad, Zev Rosenwaks, Gianpiero D. Palermo

ESHRE 2021 Poster DT1024_1.jpg

A Sperm Selection Technique to Mitigate Paternal Contributions to Embryo Aneuploidy

Derek Keating, Mounia Haddad, Danielle Tavares, Zev Rosenwaks, Gianpiero D. Palermo

Poster r1_sc-page-001.jpg

Neogametogenesis Via Oocyte Replication

Allison Petrini, Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

Screen Shot 2021-08-09 at 2.54.24 PM.png

Neospermatogenesis Benefits From a Three-Dimensional Culture System

Sherina Lawrence, Mounia Haddad, Zev Rosenwaks, Gianpiero D. Palermo

direct sphere-page-001.jpg

Utilization of Ultrastructural Analysis and Genomics of Spermatozoa to Better Characterize Subtle Forms of Male Factor Infertility

Kolbe Hancock, Philip Xie, Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

k hancock-page-001.jpg

Evaluating the Reproductive Potential of Azoospermic Men by Germline Mutation Profiling

Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

cheung-page-001.jpg

Unravelling Reproductive Failure by Scrutinizing the Male Germline Code

Pak Chung, Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

chung-page-001.jpg

Contact-Free Oocyte Denudation in a Chip-Scale Ultrasonic Microfluidic Device

Amir Mokhtare, Philip Xie, Benyamin Davaji, Alireza Abbaspourrad, Zev Rosenwaks, Gianpiero D. Palermo

amir-page-001.jpg

Generation of Artificial Oocytes by Two Distinct Mechanisms

Philip Xie, Allison Petrini, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

xie-page-001.jpg