ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

American Society for Reproductive Medicine Annual Meeting 2021

An Expedited and Safe Oocyte Denudation System Based on Soundwaves in a Microfluidic Chip

Philip Xie, Amir Mokhtare, Benyamin Davaji, Zev Rosenwaks, Alireza Abbaspourrad, Gianpiero D. Palermo

A Technique to Enhance the Number of Embryos for the Desired Gender

Stephanie Cheung, Philip Xie, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

Utilizing a Novel PLCZ Assay to Guide Treatment for Couples with Complete Fertilization Failure after ICSI

Danielle Tavares, Stephanie Cheung, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

Genomic Profiling of Surgically Retrieved Spermatozoa to Evaluate the Reproductive Potential of Azoospermic Men

Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

Evaluating the Male Gamete Genome to Improve ART Outcome

Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

Fertilization of Oocytes Generated from Somatic Cell Haploidization

Aysha Trout, Philip Xie, Allison Petrini, Zev Rosenwaks, Gianpiero D. Palermo

A Sperm Selection Technique to Improve Embryo Ploidy

Derek Keating, Danielle Tavares, Zev Rosenwaks, Gianpiero D. Palermo

To Test or Not To Test: Assessing PGT-A Outcomes with Increasing Maternal Age

Derek Keating, Aysha Trout, Nikica Zaninovic, Kangpu Xu, Zev Rosenwaks, Gianpiero D. Palermo

Concurrent Ultrastructural Analysis and Genomic Assessment of Spermatozoa to Accurately Diagnose Rare and Severe Forms of Male Infertility

Philip Xie, Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

Rho-Associated Protein Kinase Inhibitor Enhance Haploid Parthenogenetic Pseudo-blastomere Reprogramming Potential

Philip Xie, Allison Petrini, , Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

Optimal Method and Timing to Inseminate Oocytes Generated from Nuclear Transfer

Philip Xie, Allison Petrini, , Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

Male Haploid Cells through Direct Spherification

Sherina Lawerence, Philip Xie, Mounia Haddad, Zev Rosenwaks, Gianpiero D. Palermo

Ideal Culture Condition for Enhancing Full Implantation Development of Embryos Generated through Somatic Cell Haploidization

Aysha Trout, Philip Xie, Allison Petrini, Zev Rosenwaks, Gianpiero D. Palermo