ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

American Society for Reproductive Medicine 2022

Profiling the Male Germline Genome to Unravel its Reproductive Potential

Stephanie Cheung, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

Identifying Types of Azoospermia and Reproductive Potential By Screening for Germline Mutations

Stephanie Cheung, Zev Rosenwaks and Gianpiero D. Palermo

Replication of Mammalian Gametes of Both Sexes in a Mouse Model

Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

De Novo Gametes Generated in a Novel Three-Dimensional Culture System to Create Embryos Capable of Full Pre-Implantation Development

Mary McKnight, Philip Xie, Zev Rosenwaks, Gianpiero Palermo

Evidence to Support the Ooplasmic Role in Modulating Male Genome Integrity

Olena Kocur, Philip Xie, Carina Sung, Sydney Souness, Zev Rosenwaks, Gianpiero D. Palermo