ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

American Society for Reproductive Medicine Annual Meeting 2017

A Thorough Genetic Assessment on the Aging Male Gamete

Stephanie Cheung, Zev Rosenwaks, and Gianiero D. Palermo

Adopting Sperm Chromatin Fragmentation to Steer Toward the Appropriate ART Treatment

Alessandra Parrella, Stephen Chow, Nigel Pereira, Marc Goldstein, Zev Rosenwaks, and Gianpiero D. Palermo

Genetic Screening by Sequencing Technology to Predict Embryo Developmental Competence of the Male Gamete

Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

Proportional Oocyte Nuclear Maturation in Relation to ICSI Outcome

Alessandra Parrella, Stephen Chow, Stephanie Cheung, Nigel Pereira, Zev Rosenwaks, and Gianpiero D. Palermo

Sperm Source Influences the Extent of DNA Fragmentation and Reproductive Outcome

Alessandra Parrella, Claire O'Neill, Stephen Chow, Marc Goldstein, Zev Rosenwaks, and Gianpiero D. Palermo

Screening for Germ Cells in Surgical Specimen That Fail to Yield Spermatozoa

Claire O'Neill, Mohamad Irani, Alessandra Parrella, Zev Rosenwaks, and Gianpiero D. Palermo

Revisiting Aneuploidy Characteristics of Surgically Retrieved Spermatozoa by DNA Sequencing (NGS)

Stephanie Cheung, Phillip Xie, Zev Rosenwaks, and Gianpiero D. Palermo

Determining Embryo Developmental Competence by Measuring Expressivity of the Paternal Genome

Nigel Pereira, Stephanie Cheung, Alessandra Parrella, Claire O'Neill, Nora Nikprelevic, Zev Rosenwaks, and Gianpiero D. Palermo

Investigating the Role of Sperm-Specific RNA to Screen Men with Unexplained Infertility

Nigel Pereira, Stephanie Cheung, Alessandra Parrella, Claire O'Neill, Nora Nikprelevic, Zev Rosenwaks, and Gianpiero D. Palermo

The Impact of Maternal Age at Retrieval on the Implantation Rate of Euploid Blastocysts

Mohamad Irani, Claire O'Neill, Gianpiero D. Palermo, Vinay Gunnala, Kangpu Xu, Nikica Zaninovic, and Zev Rosenwaks

The Impact of Semen Parameters Considering the Number of Dominant Follicles and Endometrial Thickness on the Outcome of Intrauterine Insemination Following Superovulation with Clomiphene Citrate

Mohamad Irani, Vivian Lu, Stephen Chow, Derek Keating, Simone Elder, Zev Rosenwaks, and Gianpiero D. Palermo

A Simple Method to Generate Germ Cells from Male Embryonic Stem Cells

Mohamad Irani, Vivian Lu, Alessandra Parrella, Stephen Chow, Brandon Chin, Claire O'Neill, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

Embryonic Stem Cell Lines Derived from Somatic Cell Nuclear Transferred Oocytes Fertilizing With Sperm

Duancheng Wen, Stephen Chow, Stephanie Cheung, Alessandra Parrella, Gianpiero D. Palermo, and Zev Rosenwaks