ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

European Society of Human Reproduction and Embryology Annual Meeting 2019

Differentiating Mouse Embryonic Stem Cells into Primordial Germ Cell-like Cells and Early Meiotic Stages by Exposure to Adult Interstitial and Neonatal Testicular Cells

Aysha Trout, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

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Can Oocyte DNA Repair Mechanisms Counteract Impaired Sperm Genomic Integrity?

Lilli Zimmerman, Derek Keating, Alessandra Parrella, Zev Rosenwaks, and Gianpiero D. Palermo

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Can Gene Expression Profiling Help Characterize Human Spermatogenesis in Infertile Men?

Brianne Barker, Alessandra Parrella, Stephanie Cheung, Zev Rosenwaks, and  Gianpiero D. Palermo

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A Therapeutic Approach for Couples with Compromised Sperm DNA Integrity and a History of Aneuploidy Embryos

Allison Petrini, Alessandra Parrella, Philip Xie, Zev Rosenwaks, and Gianpiero D. Palermo

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Microfluidic Sperm Selection Enhances ICSI Outcomes by Selecting Spermatozoa with the Highest Chromatin Integrity

Kolbe Hancock, Alessandra Parrella, Matthew Goldman, Zev Rosenwaks, and Gianpiero D. Palermo

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Assessing Male Gamete Production and the Impact of Spermatozoa from Azoospermic Men on Embryonic Development by Genome Profiling

Alexis Melnick, Stephanie Cheung, Zev Rosenwaks, and Gianpiero D. Palermo

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Interpreting the Spermatogenic Profile of NOA Men Through Transcriptome Analysis

Alessandra Parrella, Brianne Barker, Zev Rosenwaks, and Gianpiero D. Palermo

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Differentiation of Embryonic Stem Cells into Germ Line Cells using Decellularized Seminiferous Tubules Bathed in a Conditioned Medium

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

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Mapping the Genital Tract: Using Male Gamete Genomic Integrity to Guide Reproductive Outcome

Robert Setton, Philip Xie, Derek Keating, Alessandra Parrella, Marc Goldstein, Zev Rosenwaks, Gianpiero D. Palermo

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