ICSI Center

LABORATORY OF ADVANCED REPRODUCTIVE BIOLOGY AND GENETICS

We are dedicated to implementing cutting-edge research in the field of Reproductive Biology. Our primary emphasis lies in exploring the complexities of human gametes–spermatozoa and oocytes–to gain insights into their maturation processes and interactions. Beyond that, our investigation extends to understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

European Society of Human Reproduction and Embryology Annual Meeting 2020

Three-Dimensional Culture of Mouse Embryonic Stem Cells Maintained on a Biological Scaffold Through Direct Spherification

Sherina Lawrence, Mounia Haddad, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

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Feasibility of Parental Genome Cloning

Philip Xie, Aysha Trout, Robert Setton, Zev Rosenwaks, and Gianpiero D. Palermo

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Epigenetic Assessment by RNA Sequencing of Non-Obstructive Azoospermic Men to Predict Successful Testicular Sperm Retrieval

Kolbe Hancock, Alessandra Parrella, Stephanie Cheung, Brianne Barker, Zev Rosenwaks, and  Gianpiero D. Palermo

Epigenetic Assess. by RNA Seq of NOA men to Predict Successful TESE Sperm Retrieval R3.jpg

The Impact of Double-Stranded DNA Breaks in Human Spermatozoa on Embryo Implantation

Lilli Zimmerman, Derek Keating, Alessandra Parrella, Zev Rosenwaks, and Gianpiero D. Palermo

Ooplasmic DNA Repair Mechanisms of the Human Gamete Appear to be Linked to Oocyte Maturity

Derek Keating, Alessandra Parrella, Zev Rosenwaks, and Gianpiero D. Palermo

Somatic Cell Nuclear Transfer of Different Diploid Cells Into an Enucleated Oocyte Aimed at Nuclear Haploidization

Aysha Trout, Philip Xie, Robert Setton, Zev Rosenwaks, and Gianpiero D. Palermo

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Selecting Spermatozoa With the Highest Chromatin Integrity

Joshua D. Stewart, Alessandra Parrella, Danielle Tavares, June Wang, Mounia Haddad, Zev Rosenwaks, and Gianpiero D. Palermo

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Varicocelectomy Corrects Sperm Capacitation Functions and Enhances Sperm Genomic Integrity

Mounia Haddad, Philip Xie, Alessandra Parrella, Zev Rosenwaks, and Gianpiero D. Palermo

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Progress Towards Manufacturing Oocytes

Robert Setton, Aysha Trout, Philip Xie, Zev Rosenwaks, and Gianpiero D. Palermo

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Differentiation of Embryonic Stem Cells into Germ Line Cells using Decellularized Seminiferous Tubules Bathed in a Conditioned Medium

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

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Mapping the Genital Tract: Using Male Gamete Genomic Integrity to Guide Reproductive Outcome

Robert Setton, Philip Xie, Derek Keating, Alessandra Parrella, Marc Goldstein, Zev Rosenwaks, Gianpiero D. Palermo

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